Gene name:
PKLR (PK1;PKL) ;
Protein name:
Pyruvate kinase isozymes R/L ;
Alternative:
R-type/L-type pyruvate kinase ;Pyruvate kinase 1 ;Red cell/liver pyruvate kinase ;Red cell/liver pyruvate kinase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Plays a key role in glycolysis.
Subcellular Location:
N/A
Protein Attributes:
50:
MSIQENISSL | QLRSWVSKSQ | RDLAKSILIG | APGGPAGYLR | RASVAQLTQE |
100:
LGTAFFQQQQ | LPAAMADTFL | EHLCLLDIDS | EPVAARSTSI | IATIGPASRS |
150:
VERLKEMIKA | GMNIARLNFS | HGSHEYHAES | IANVREAVES | FAGSPLSYRP |
200:
VAIALDTKGP | EIRTGILQGG | PESEVELVKG | SQVLVTVDPA | FRTRGNANTV |
250:
WVDYPNIVRV | VPVGGRIYID | DGLISLVVQK | IGPEGLVTQV | ENGGVLGSRK |
300:
GVNLPGAQVD | LPGLSEQDVR | DLRFGVEHGV | DIVFASFVRK | ASDVAAVRAA |
350:
LGPEGHGIKI | ISKIENHEGV | KRFDEILEVS | DGIMVARGDL | GIEIPAEKVF |
400:
LAQKMMIGRC | NLAGKPVVCA | TQMLESMITK | PRPTRAETSD | VANAVLDGAD |
450:
CIMLSGETAK | GNFPVEAVKM | QHAIAREAEA | AVYHRQLFEE | LRRAAPLSRD |
500:
PTEVTAIGAV | EAAFKCCAAA | IIVLTTTGRS | AQLLSRYRPR | AAVIAVTRSA |
550:
QAARQVHLCR | GVFPLLYREP | PEAIWADDVD | RRVQFGIESG | KLRGFLRVGD |
574:
LVIVVTGWRP | GSGYTNIMRV | LSIS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Dog
ELISA Kit for Human Pyruvate kinase isozymes R/L
ELISA Kit for Human Pyruvate kinase isozymes R/L
ELISA Kit for Human Pyruvate kinase isozymes R/L
ELISA Kit for Human Pyruvate kinase isozymes R/L
CLIA Kit for Human Pyruvate kinase isozymes R/L
CLIA Kit for Human Pyruvate kinase isozymes R/L
CLIA Kit for Human Pyruvate kinase isozymes R/L
CLIA Kit for Human Pyruvate kinase isozymes R/L
Polyclonal Antibody for Human Pyruvate kinase isozymes R/L
Polyclonal Antibody for Human Pyruvate kinase isozymes R/L
Polyclonal Antibody for Human Pyruvate kinase isozymes R/L
Polyclonal Antibody for Human Pyruvate kinase isozymes R/L
Monoclonal Antibody for Human Pyruvate kinase isozymes R/L
Monoclonal Antibody for Human Pyruvate kinase isozymes R/L
Monoclonal Antibody for Human Pyruvate kinase isozymes R/L
Monoclonal Antibody for Human Pyruvate kinase isozymes R/L
Protein for Human Pyruvate kinase isozymes R/L
Protein for Human Pyruvate kinase isozymes R/L
Protein for Human Pyruvate kinase isozymes R/L
Protein for Human Pyruvate kinase isozymes R/L
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT PKRD MET-384
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
Kanno H.
Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 130 AND 232
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-506
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM R-TYPE)
tissue :
Pancreas .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 470-574
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 365-431;VARIANT PKRD PHE-368
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.73 ANGSTROMS) OF 47-574 IN COMPLEX WITH FRUCTOSE 1,6-BISPHOSPHATE;ALLOSTERIC ACTIVATION;ENZYME REGULATION;CHARACTERIZATION OF VARIANTS PKRD SER-332; ASP-364; ASN-390; HIS-479; TRP-486; LEU-504 AND TRP-532;CHARACTERIZATION OF VARIANT MET-384;SUBUNIT
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD CYS-163 AND MET-384
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKRD LYS-421
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKRD GLN-426
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD ASP-134; PRO-155; HIS-359; TRP-486; VAL-495 AND GLN-510
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKRD HIS-479
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD SER-332; SER-336; LYS-354 DEL; ASP-361; THR-392; HIS-498; GLN-510 AND TRP-532
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD GLU-331; ALA-341; LYS-393; SER-393; ASP-458; MET-460 AND HIS-498
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKHYP GLU-37
25.
"Molecular characterization of the PK-LR gene in pyruvate kinase deficient Spanish patients."
Zarza R.
,
Alvarez R.
,
Pujades A.
,
Nomdedeu B.
,
Carrera A.
,
Estella J.
,
Remacha A.
,
Sanchez J.M.
,
Morey M.
,
Cortes T.
,
Perez Lungmus G.
,
Bureo E.
,
Vives Corrons J.L.
Br. J. Haematol.103:377-382(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD GLN-172; GLN-337; HIS-339; THR-357; ILE-408; THR-431; TRP-486 AND GLN-532
26.
"A new sickle cell disease phenotype associating Hb S trait, severe pyruvate kinase deficiency (PK Conakry), and an alpha-2 globin gene variant (Hb Conakry)."
Cohen-Solal M.
,
Prehu C.
,
Wajcman H.
,
Poyart C.
,
Bardakdjian-Michau J.
,
Kister J.
,
Prome D.
,
Valentin C.
,
Bachir D.
,
Galacteros F.
Br. J. Haematol.103:950-956(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKRD TYR-130
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD SER-332; PRO-337; TRP-486; CYS-498 AND GLN-510
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD MET-335; LYS-348 DEL; GLY-387; ASP-394 AND VAL-394
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD TRP-40; 48-THR--THR-53 DEL; PRO-73; ASN-90; ARG-111; THR-154; LEU-163; VAL-165; VAL-272; ASN-310; LEU-320; GLU-358 AND PRO-374
30.
"Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications."
Lyon G.J.
,
Jiang T.
,
Van Wijk R.
,
Wang W.
,
Bodily P.M.
,
Xing J.
,
Tian L.
,
Robison R.J.
,
Clement M.
,
Lin Y.
,
Zhang P.
,
Liu Y.
,
Moore B.
,
Glessner J.T.
,
Elia J.
,
Reimherr F.
,
van Solinge W.W.
,
Yandell M.
,
Hakonarson H.
,
Wang J.
,
Johnson W.E.
,
Wei Z.
,
Wang K.
more...
Discov. Med.12:41-55(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKRD ALA-341 AND GLN-569